Biography

Celine Buchmann is researching the role of bacterial stimuli for the protease release of immune cells in inflammatory processes. The focus here is on the interaction between formyl peptide receptors (FPRs) and matrix metalloproteinase-9 (MMP-9), which enables leukocyte migration to the site of inflammation. This interaction must be strictly regulated for the innate immune system to successfully eliminate bacterial pathogens. While there is clear evidence that bacteria can differ in their ability to activate different FPR subtypes, the extent to which this affects MMP-9 activity and cell migration is currently unknown. Celine Buchmann will be investigating this as part of the MultiSensE research college. The long-term goal of the research college is to develop a biosensor that enables multiparametric measurements of the release and activity of proteases.